購(gòu)物車
幫助
021-54845833/15800441009
技術(shù)規(guī)格
|
Background: |
This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |
|
Applications: |
WB, IHC, FC |
|
Name of antibody: |
PYCARD |
|
Immunogen: |
Fusion protein of human PYCARD |
|
Full name: |
PYD and CARD domain containing (PYCARD), transcript variant 1 |
|
Synonyms: |
ASC; CARD5; TMS; TMS-1; TMS1 |
|
SwissProt: |
Q9ULZ3 |
|
IHC positive control: |
carcinoma of human pancreas tissue and human tonsil tissue |
|
IHC Recommend dilution: |
30-150 |
|
WB Predicted band size: |
22 kDa |
|
WB Positive control: |
A549, MCF-7 cell lysates |
|
WB Recommended dilution: |
200-1000 |
